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JWH-018 or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂
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buy JWH-018 online is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype approximately 10x the affinity at CB2. It was discovered by and named after John W. Huffman.
buy JWH-018 online may be neurotoxic to animals when administered in high doses.
In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as buy JWH-018 online are Schedule I Controlled Substances.
On 1 October 2010, JWH-210 and other cannabinoids were classified as hazardous goods harmful to health, after being identified as ingredients in “herbal” synthetic cannabis products. JWH-210 and related substances have since 1 September 2011 been classified under Swedish law as illegal drugs. John W. Huffman is the individual who first synthesized these chemicals, which are often referred to by users as “John W.” buy JWH-018 online
As of October 2015 JWH-210 is a controlled substance in China
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JWH-018 can cause severe anxiety, agitation, and, in rare cases (usually with irregular JWH users), it has been hypothesized to have caused seizures and fits by inhibiting the GABA neurotransmitter more effectively than THC.
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The highest reported concentration of JWH-018 in our study was 87 ng/mL at 15 minutes after administration, which is 9 to 17 times higher than the value published in post-inhalation controlled human studies 18, 28, where doses are far from being Toxic for humanitarian purposes and security reasons
JWH-018 is an aminoalkylindole that is used as the active ingredient in products sold as cannabis alternatives. When smoked, JWH-018 produces cannabinoid-mimicking effects at doses lower than the doses of Δ9-tetrahydrocannabinol (THC) required to produce effects of similar potency (higher potency).
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A stock solution can be prepared by dissolving the JWH 018 N-(1-ethylpropyl) isomer in the chosen solvent. JWH 018 N-(1-ethylpropyl) isomer is soluble in organic solvents such as ethanol, DMSO and dimethylformamide (DMF), which should be purged with inert gas.
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