buy AM-2201 online/AM2201

270.00$3,600.00$

AM-2201 is a stimulant drug that acts as a powerful however nonselective complete agonist for the cannabinoid receptor. It is a part of the AM collection of cannabinoids .

This product maybe illegal but not impossible to ship or sell . We’re telling you the legal status of this product just for information use but we still supply them without problem .

Clear
N/A

Description

— what’s AM-2201 / AM2201 ? —

buy AM-2201 online/AM2201 . AM-2201 is an aminoalkylindole used as an energetic factor of merchandise offered as hashish substitutes. When smoked, AM-2201 produces cannabimimetic results in doses decrease than the doses of Δ9-tetrahydrocannabinol (THC) had to produce results of comparable strength (better potency).

Many of the dangers connected to hashish use also are gift withinside the case of AM-2201, amongst them headaches in sufferers tormented by cardiovascular illnesses and triggering of acute psychosis. Abuse ability and dependence ability appear to be much like hashish. One of the primary variations among hashish and this artificial cannabinoid is the extra acute toxicity of AM-2201. buy AM-2201 online/AM2201

Due to its complete agonistic movement on the CB1 receptor and enormously excessive potency, the aspect results of better doses may be life-threatening. This is annoyed with the aid of using the reality that dosing could be very hard because of converting contents of energetic elements in unique merchandise, unique batches of the equal product or even inside one packet. Regarding continual toxicity, dangers are very hard to estimate on the idea of the to be had data.

However, there are issues approximately ability carcinogenic results. In comparison to JWH-018 and JWH-073, AM-2201 consists of a fluorine atom on the five role of the alkyl aspect chain, that is challenge to metabolic transformation and offers upward push to extra challenge in regards to ability toxicity . buy AM-2201 online/AM2201

 

AM-2201.svg

— AM-2201/AM2201 liquid —

AM2201 (Item No. 10707) is an analytical reference fabric characterised as a artificial cannabinoid. AM2201 is regulated as a Schedule I compound withinside the United States. This product is supposed for studies and forensic applications.

— Substance identification — buy AM-2201 online/AM2201

-International Nonproprietary Name (INN) : Not applicable

-Chemical Abstract Service (CAS) Registry Number : 335161-24-5

-Other Names : AM-2201, AM2201, 1-(5-fluoropentyl)-3-(1-naphthoyl)indole, JWH 2201

– Street Names : ‘Spice’, ‘K2’, ‘felony weed’, ‘artificial cannabis’, ‘natural incense’
AM-2201 become located as an additive in over ninety specific manufacturers of ‘natural combinations’ in Germany alone (personal unpublished information). These merchandise had been sporting fable names like e.g.: ‘Agent Orange’, ‘Atomic Bomb’, ‘Green’, ‘Jamaican Gold Extreme’, ‘Manga Xtreme’, ‘New Bonzai’ and ‘XoXo’.

One must be aware about the truth that combinations offered beneath unique emblem names do now no longer constantly comprise the equal substance or aggregate of materials over time.

– Physical properties : White crystalline solid (in natural form), soluble at ~5mg/ml in ethanol.

– WHO Review History on buy AM-2201 online/AM2201

AM-2201 become now no longer formerly pre-reviewed or significantly reviewed. A direct essential overview is being proposed primarily based totally on statistics introduced to WHO’s interest that AM-2201 is clandestinely manufactured, of in particular severe chance to public fitness and society, and of no identified healing use with the aid of using any party.

Preliminary information amassed from literature and specific international locations indicated that this substance can also additionally purpose massive damage and that it has no clinical use . buy AM-2201 online/AM2201

— Chemical Structure of AM-2201/AM2201 —

Molecular Formula: C24 H 22 FNO
Molecular Weight: 359.43 g/mol
Melting point: 93.7 °C
Boiling point: n/a
Fusion point: n/a

— Synthesis of AM-2201/AM2201 —

Synthesis of AM-2201 changed into first suggested in 2001 with the aid of using Alexandros Makriyannis and Hongfeng Deng . Starting from a 1-H indole answer in acetic acid ethyl ester, an answer of methyl magnesium bromide in acetic acid ethyl ester is introduced. buy AM-2201 online/AM2201

Then, naphthalene-1-carbonyl chloride (organized from naphthalene-1-carboxylic acid and thionyl chloride) is introduced, accompanied with the aid of using the addition of an aqueous answer of ammonium chloride. Afterwards, the received filtrate of 1H-indol-three- yl(naphthalen-1-yl)methanone is washed and recrystallized. buy AM-2201 online/AM2201

This product is introduced to a suspension of sodium hydride in dimethylformamide (DMF) accompanied with the aid of using the addition of five bromopentylacetate for N-al kylation. After cleavage of the acetate the use of a methanolic potassium hydroxide answer, fluorination of the pentyl facet chain is done using diethylaminosulfur trifluoride (DAST) and dichloromethane .

Commercially to be had home or commercial merchandise, which can be used for synthesis, may also include different doubtlessly poisonous materials, which includes heavy metals and natural solvents. Use of such merchandise as reagents may also bring about critical poisonous outcomes if the ensuing impure product is consumed. buy AM-2201 online/AM2201

The natural cloth that is used as a foundation for the smoking combos may also include toxicologically applicable materials like e.g. pesticides, too. buy AM-2201 online/AM2201

— Chemical description of AM-2201/AM2201 —

AM-2201 is a naphthoylindole alkylated on the indole nitrogen and includes a fluorine atom on the five-function of the pentyl facet chain.

— Chemical residences of AM-2201/AM2201 —

Chemically, AM-2201 may be appeared as notably inert as it’s miles substituted on the reactive C-three function with the naphthoyl moiety. Due to the aromaticity of the indole device the nitrogen does now no longer result in great basicity. In comparison to non-fluorinated analogues, at better temperatures AM-2201 can be transformed into JWH-018 and JWH-022 to a minor extent . buy AM-2201 online/AM2201

— AM-2201/AM2201 Chemical identification —

The analytical profile of AM-2201 has been defined in numerous papers. Utilized techniques encompass LC-MS/MS , GC-EI-MS , LC-Q-ToF-MS , AccuTOF-DART , NMR , FTIR ATR and UV-VIS detection . Detection in organic matrices turned into defined in serum , complete blood , hair and oral fluid concentrated on AM-2201. In urine samples, the primary metabolites are the analytical targets . buy AM-2201 online/AM2201

— Ease of convertibility into managed materials with AM-2201/AM2201 —

When heated (e.g. throughout smoking), AM-2201 can be transformed into JWH-018 to a minor extent , which turned into one of the first artificial cannabinoids to be covered into numerous country wide narcotics laws. However, AM-2201 isn’t taken into consideration an instantaneous precursor of any the world over managed substance. buy AM-2201 online/AM2201

— AM-2201/AM2201 General pharmacology —

*** Pharmacodynamics of AM-2201/AM2201 ***

In vivo information on pharmacodynamics of AM-2201 have now no longer been posted so far. However, AM-2201 possesses a fantastically excessive binding affinity (expressed as IC50 (profession of 50% of the receptors)) closer to the cannabinoid receptor kind 1 (CB1) of 1.zero nM and closer to the cannabinoid receptor kind 2 (CB2) of 2.6 nM in comparison tothe binding affinities of delta-nine tetrahydrocannabinol (THC) of 40.7 ± 1.7 nM on the CB1 and 36.4 ± 10 nM on the CB2 receptor . buy AM-2201 online/AM2201

Furthermore, Nakajima et al. and Chimalakonda et al. examined the organic outcomes with the aid of using making use of an in vitro guanosine-5’-O-(3-thio)-triphosphate (GTPγS) binding assay, measuring an 50 fictive concentration (EC50) of zero.24 nMand complete agonistic properties .

Based in this information and medical observations, it may be assumed that AM-2201 suggests standard outcomes of CB1 agonists. These outcomes can encompass sedation, cognitive dysfunction, tachycardia, postural hypotension, dry mouth, ataxia, immunosuppression and psychotropic outcomes . buy AM-2201 online/AM2201

A reported distinction with reference to THC is the formation of doubtlessly pharmacologically energetic AM-2201 metabolites. While withinside the case of THC, handiest one of the predominant THC-metabolites is understood to be psychoactive and keeps binding affinity closer to cannabinoid receptors (11-OH-THC: Ki at CB1 receptor: 38.4 ± zero.eight nM), numerous AM-2201 metabolites preserve excessive CB1 receptor binding affinity (relative rank of binding affinities: AM-2201 > AM-2201 N-(4-OH-pentyl) = JWH-018 N-(5-OH- pentyl) > THC > JWH-073 N-(4-OH-butyl)) .

Furthermore, comparable efficacy for AM-2201 (a complete agonist) and the 2 AM-2201 metabolites AM-2201 N-(4-OH- pentyl) and JWH-018 N-(5-OH-pentyl) has been proven and partial agonistic pastime for JWH-073 N-(4-OH-butyl. The glucuronidated JWH-018 N-(5-OH-pentyl) metabolite keeps binding affinity closer to the CB1 receptor and pastime as a impartial antagonist (Ki: 922 nM). buy AM-2201 online/AM2201

No information is to be had regarding the query whether or not this metabolite of JWH-018 is able to antagonizing pharmacological outcomes of JWH-018 in vivo, and if enough concentrations are shaped on the web website online of action . buy AM-2201 online/AM2201

*** Neuropharmacology and outcomes at the vital frightened gadget of AM-2201/AM2201 ***

No look at information to be had.

*** Effects on cardiovascular, respiratory, gastrointestinal, liver, kidneys and genitourinary systems ***

No look at information to be had.

*** Behavioural research in animals ***

No look at information to be had.

*** Effects on cognition in humans ***

No look at information to be had.

*** AM-2201/AM2201 Effects in humans ***

There isn’t anyt any information of systematic research to be had for AM-2201 withinside the medical literature so far. However, primarily based totally on case reviews and on person reviews from the Internet, there may be a few proof of bioavailability after smoking and oral uptake, and standard outcomes appear to imitate the outcomes of hashish consumption.

*** AM-2201/AM2201 Interactions with different materials and medicines ***

No look at information to be had.

— Routes of administration and dosage of AM-2201/AM2201 —

AM-2201 is mainly offered on the Internet either in the form of ‘herbal mixtures’, where the chemical has been sprayed on plant material (e.g. damiana), or as a powder . Based on user reports and on the dosage forms offered, the primary route of administration is inhalation either by smoking the ‘herbal mixture’ as a joint or utilizing a vaporizer, ‘bong’ or pipe . Furthermore, oral uptake of the compound was described by various users on internet fora . buy AM-2201 online/AM2201

Based on such information from the Internet, active doses start from 250 μg when smoked/vaporized . Based on data
from the EMCDDA, 250 μg is considered a light dose, 500-1,000 μg moderate, 1-2 mg a heavy dose and 3 mg can cause hallucinations and extreme anxiety .

When taken orally, Hutter et al. reported no physical or psychoactive effect after a 5 mg dose ,which is most probably a consequence of a pronounced ‘first pass effect’ in combination with a relatively slow resorption in the gastro-intestinal tract.

AM-2201 contents in various ‘herbal mixtures’ purchased in Germany , Japan , Korea and the USA varied from 0.9 to 303 mg/g. It has to be considered that many of the ‘herbal mixtures’ are inhomogeneous with respect to the content of active ingredients, as it has been shown by Logan et al., Ng et al.,

Langer et al. and Choi et al. The latter analysed eleven samples of one ‘herbal mixture’ detecting an extremely high variation of the AM-2201 content, ranging from 0.9 to 36.6 mg/g (mean 14.5 mg/g).

— Toxicology of AM-2201/AM2201 —

Toxicity of AM-2201 has so far only been investigated on primary neuronal cells of the forebrain, showing an induction of cytotoxicity in a concentration-dependent manner . Using preincubation with the CB1 selective antagonist AM-251, AM-2201 cytotoxicity (30 μM) was suppressed, indicating an important role of CB1 receptors in the induction of cytotoxicity in this cell line rather than other mechanisms.

Furthermore, the AM-2201 cytotoxicity proceeded via apoptosis and was mediated by caspase enzymes, revealing a strong neurotoxic effect according to the authors. buy AM-2201 online/AM2201

However, considering the concentrations tested in the above study (10 μM and 30 μM AM-2201), conclusions on the cytotoxicity in vivo have to be drawn with care, as serum concentration levels published in the literature or from routine sample analysis (own unpublished data) were not higher than 33.4 nM (12 ng/ml) and are therefore about 300- fold lower than the concentrations applied by Tomiyama et al.;

Nevertheless, due to the lipophilic character of AM-2201, it can not be excluded that higher concentrations may occur in deeper compartments (accumulation) or in epithelial cells of the aerodigestive tract (which are directly exposed to smoke or pure substance). buy AM-2201 online/AM2201

Apart from this study, no data regarding the toxicity of AM-2201 is published in the literature so far, and in particular there is no data on potential teratogenic effects. However, it has to be noted that the endocannabinoid system is present from conception onwards in the developing central nervous system and that THC, as well as the cannabimimetic WIN-55,212-2, interfere with the endocannabinoid system to cause anencephaly and neurobehavioral deficiencies in the offspring .

It is not known whether AM-2201 crosses the placental barrier. However, based on its physico- chemical properties, it can be assumed to effectively reach the fatal tissues via the placenta. buy AM-2201 online/AM2201

— AM-2201/AM2201 adverse reactions in humans —

Cases of AM-2201 intoxications in humans published in the literature:

*** Non-fatal Cases of AM-2201/AM2201 ***

Adverse effects described in the literature after the consumption of synthetic cannabinoids include tachycardia, agitation, hallucination, hypertension, minor elevation of blood glucose, hypokalemia, vomiting, chest pain, seizures, myoclonia,
extreme anxiety leading to panic attacks and acute psychosis (risk of suicide) . buy AM-2201 online/AM2201

In cases with analytically verified AM-2201 consumption convulsions, vomiting, drowsiness, tachycardia, cannabinoid hyperemesis syndrome, and diffuse pulmonary infiltrates were reported. A 19-year-old man suffered from two generalized convulsions lasting for 1-2 min, and vomited soon after smoking an ‘herbal mixture’ containing JWH-018, JWH-081, JWH-250 and AM-2201 .

A 40 year old man was admitted to the hospital after he was found drowsy and in a slow reacting condition at home after
smoking of self-estimated 0.5 g of a ‘herbal mixture’ (AM-2201 and trace amounts of AM-2232), and consumption of α-methyltryptamine and a benzodiazepine-like substance. In this case 3.1 ng/ml AM-2201 was detected in the obtained serum samples
. A diffuse pulmonary infiltrate was diagnosed in a 21-year-old male and an infectious aetiology appeared unlikely . buy AM-2201 online/AM2201

Blood, urine and saliva analysis confirmed the uptake of AM-2201 (blood level: 0.75 ng/ml), JWH-122 and JWH-210 and it emerged that the patient smoked multiple brands of ‘herbal mixtures’ during the preceding four months . Hopkins et al. report a case of cannabinoid hyperemesis syndrome in a consumer with a self-reported highly frequent synthetic cannabinoid consumption who had developed recurring and severe crampy abdominal pain associated with intractable nausea and vomiting.

Urine samples of the patient tested positive for JWH-018, JWH- 073 and AM-2201, and negative for THC. Furthermore, the patient reported that after two weeks of sobriety his symptoms completely resolved . buy AM-2201 online/AM2201

— Fatal cases of AM-2201/AM2201 —

Three fatal cases in which AM-2201 could be detected in post-mortem blood samples were published so far. One occurred in Germany, where a 36-year-old man collapsed after smoking a ‘herbal mixture’. He suffered from seizures and died after admission to the hospital despite continued resuscitation attempts.

buy AM-2201 online/AM2201 . The residue of the joint he had consumed contained JWH-122, AM-2201, MAM-2201 and UR-144. AM-2201 could be detected in the femoral blood sample of the deceased at a concentration of 1.4 ng/ml as well as in the brain (~0.1 ng/g), lung (~ 2.0 ng/g), bile fluid (~5.9 ng/ml), gastric content (~270 μg absolute), hair (~ 3.0 ng/mg) and adipose tissue (~ 180 ng/g). buy AM-2201 online/AM2201

Furthermore, the synthetic cannabinoids JWH-018 (0.1 ng/ml), JWH-122 (0.3 ng/ml), MAM-2201 (1.5 ng/ml) and UR-144 (6 ng/ml) as well as a relatively high concentration of amphetamine (250 ng/ml) were also detect ed in the femoral blood, indicating an acute influence of several synthetic cannabinoids and amphetamine . In this case, the presence of various substances in the femoral blood prevents a realistic estimation of the contribution of AM-2201 to the lethal outcome.

The second fatality occurred in the USA, where a 23-year-old man with no history of mental illness, seizure disorder, previous psychiatric care or past or current use of antipsychotic or illicit drugs was found dead lying supine on the floor. The ‘herbal mixture’ found in the decedent’s shirt pocket contained 0.8 ± 0.2 % of AM-2201 by weight and the found smoking device contained high concentrations AM-2201 and trace amounts of JWH-073. buy AM-2201 online/AM2201

buy AM-2201 online/AM2201 . In the post-mortem blood sample 12 ng/ml AM-2201 along with 2.5 ng/ml of an oxidized metabolite of AM-2201 were detected, and no further drugs of abuse (opiates, benzodiazepines, amphetamines, cocaine, THC) or alcohol were found. A post-mortem examination of the descendent revealed many self-inflicted blunt and sharp force wounds, including a self-inflicted stab wound to the right side of the neck considered fatal, thus concluding the manner of death to be related to psychiatric complications after AM-2201 use.

The third case describes a fatal methoxetamine intoxication of a 26-year-old male in Sweden, where it cannot be ruled out that the presence of three synthetic cannabinoids (femoral blood: AM-2201 0.3 ng/g, AM-694 0.09 ng/ml and JWH-018 0.05 ng/g) may have contributed to the lethal outcome. buy AM-2201 online/AM2201

— LEGITIMATE USE of AM-2201/AM2201 —

None reported that AM-2201 was currently authorized or in the process of being authorized/registered as a medical product in their country. Four respondents stated that this substance was used in medical and scientific research including as standard in analyses. There was no use stated for AM-2201 in animal/veterinary care .

— HARMFUL USE of AM-2201/AM2201 —

Twenty-two respondents confirmed that there was recreational/harmful use of AM-2201; common routes of administration stated as oral by one, inhaling/sniffing by 14 and oral, injection, inhaling/sniffing by two. Twelve respondents stated this was obtained only via trafficking, one only via diversion, one via diversion and trafficking, one via clandestine manufacturing and three via trafficking and clandestine manufacturing. buy AM-2201 online/AM2201

Twelve reported powder as the available formulation, and one each tablet; powder and tablet; powder, liquid and powder, tablet, liquid forms. Six respondents also mention that AM-2201 is often found in herbal mixtures. Five respondents state that it is used only in the general population, three only in clubs and one that it was used both by the general population and in clubs, and. In 2012 one respondent reported 2 deaths due to AM-2201.

This same respondent reported 10 emergency room visits in 2012 and another reported 5 visits. Five respondents reported withdrawal, tolerance and other adverse effects or medical illnesses caused by AM-2201. These included vomiting, anxiety, agitation, paranoia, irritability, seizures, tachycardia, self-inflicted injuries, hallucinations (visual and acoustical), dyspnoea, apnoea, spasms, cardiac arrest, panic attacks, somnolence, hypokalemia, concentration and coordination difficulties, elevated blood pressure, and loss of consciousness.

One respondent reported drug related crimes involving postal delivery of NPS.

— AM-2201/AM2201 CONTROL —

buy AM-2201 online/AM2201 . Of those with information on this substance, 26 reported that AM-2201 was controlled under legislation that was intended to regulate its availability; 18 under “controlled substance act”, five under “medicines law”, one “temporary ban” and two under “other” laws. Only four respondents stated that there were challenges with the implementation of this legislation.

On illicit activities involving this substance, four respondents reported clandestine manufacture. Eleven respondents reported processing into the consumer product, 18 reported trafficking, three reported diversion and 16 an internet market . buy AM-2201 online/AM2201

— Where to Buy AM-2201/AM2201 —

 

Additional information

Package

100g, 1kg, 300g, 500g, 50g

error: Content is protected !!